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Peter Olson Selected Research

nirogacestat

10/2018Synergistic antitumor effect of a γ-secretase inhibitor PF-03084014 and sorafenib in hepatocellular carcinoma.
1/2017Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3.
3/2015PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.

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Peter Olson Research Topics

Disease

24Neoplasms (Cancer)
10/2022 - 10/2003
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 01/2013
4Insulin Resistance
02/2006 - 06/2003
3Neoplasm Metastasis (Metastasis)
11/2017 - 09/2009
2Hepatocellular Carcinoma (Hepatoma)
10/2018 - 01/2017
2Pancreatic Neoplasms (Pancreatic Cancer)
03/2016 - 12/2011
2Colorectal Neoplasms (Colorectal Cancer)
01/2016 - 11/2014
2Breast Neoplasms (Breast Cancer)
03/2015 - 03/2004
2Adenocarcinoma
12/2011 - 04/2011
2Neuroendocrine Tumors (Neuroendocrine Tumor)
12/2011 - 02/2010
2Inflammation (Inflammations)
02/2010 - 03/2008
2Obesity
12/2003 - 06/2003
1Brain Neoplasms (Brain Tumor)
01/2022
1Squamous Cell Carcinoma of Head and Neck
10/2021
1Hypoxia (Hypoxemia)
10/2021
1Carcinoma (Carcinomatosis)
10/2021
1Hypertension (High Blood Pressure)
10/2021
1Thrombocytopenia (Thrombopenia)
10/2021
1Colonic Neoplasms (Colon Cancer)
01/2020
1Lung Neoplasms (Lung Cancer)
11/2017
1Disease Progression
01/2016
1Fibrosis (Cirrhosis)
12/2015
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
12/2015
1Triple Negative Breast Neoplasms
03/2015
1Cardiomyopathies (Cardiomyopathy)
10/2014
1Myocarditis (Carditis)
01/2012
1Ductal Carcinoma
12/2011
1Primitive Neuroectodermal Tumors (PNET)
12/2011
1Type 2 Diabetes Mellitus (MODY)
12/2009
1Carcinogenesis
09/2009
1Vascular Diseases (Vascular Disease)
03/2008
1Atherosclerosis
03/2008

Drug/Important Bio-Agent (IBA)

6adagrasibIBA
01/2022 - 01/2020
5PPAR gammaIBA
12/2009 - 10/2003
3Proteins (Proteins, Gene)FDA Link
10/2022 - 01/2018
3Pharmaceutical PreparationsIBA
10/2022 - 06/2003
3LigandsIBA
01/2022 - 03/2004
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
10/2018 - 03/2015
3nirogacestatIBA
10/2018 - 03/2015
2Biomarkers (Surrogate Marker)IBA
10/2021 - 01/2016
2RNA (Ribonucleic Acid)IBA
10/2021 - 01/2021
2Phosphotransferases (Kinase)IBA
10/2018 - 11/2014
2CrizotinibIBA
11/2017 - 01/2013
2Angiogenesis InhibitorsIBA
12/2011 - 09/2009
2ThiazolidinedionesIBA
12/2009 - 12/2003
2PPAR deltaIBA
03/2008 - 02/2006
2Fatty Acids (Saturated Fatty Acids)IBA
02/2006 - 06/2003
2Peroxisome Proliferator-Activated Receptors (PPAR)IBA
10/2003 - 06/2003
1symmetric dimethylarginineIBA
10/2022
1KRASG12D inhibitor MRTX1133IBA
01/2022
1sitravatinibIBA
10/2021
1Cell-Free Nucleic AcidsIBA
10/2021
1Circulating Tumor DNAIBA
10/2021
1NivolumabIBA
10/2021
1Biological ProductsIBA
10/2021
1sotorasibIBA
01/2021
1Codon (Codons)IBA
01/2021
1Cysteine (L-Cysteine)FDA Link
01/2021
1serum P-component (CIt)IBA
01/2021
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2021
1Blood Proteins (Serum Proteins)IBA
01/2021
1Sorafenib (BAY 43-9006)FDA Link
10/2018
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2018
1Histone Deacetylases (Histone Deacetylase)IBA
01/2018
1mocetinostatIBA
01/2018
1DNA (Deoxyribonucleic Acid)IBA
11/2017
1glesatinibIBA
11/2017
1Gamma Secretase Inhibitors and ModulatorsIBA
01/2017
1ibrutinibIBA
03/2016
1Agammaglobulinaemia Tyrosine KinaseIBA
03/2016
1Notch1 ReceptorIBA
01/2016
1Indicators and Reagents (Reagents)IBA
01/2016
1GadoliniumIBA
12/2015
1Notch ReceptorsIBA
03/2015
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
11/2014
1Sirolimus (Rapamycin)FDA Link
11/2014
1Transcription Factors (Transcription Factor)IBA
11/2014
1dacomitinibIBA
11/2014
12- amino- 8- (4- (2- hydroxyethoxy)cyclohexyl)- 6- (6- methoxypyridin- 3- yl)- 4- methylpyrido(2,3- d)pyrimidin- 7(8H)- oneIBA
11/2014
1Contrast MediaIBA
01/2013
1Cyclosporine (Ciclosporin)FDA LinkGeneric
01/2012
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
12/2011
1Sunitinib (Sutent)FDA Link
12/2011
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2011
1NF-kappa B (NF-kB)IBA
02/2010
1Heparin-binding EGF-like Growth Factor (HB-EGF)IBA
02/2010
1ErbB Receptors (EGF Receptor)IBA
02/2010
1MicroRNAs (MicroRNA)IBA
09/2009
1Zinc Finger E-box-Binding Homeobox 1IBA
09/2009
1Cadherins (E-Cadherin)IBA
09/2009
1LipidsIBA
03/2008
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
03/2008
1Apolipoproteins E (ApoE)IBA
03/2008

Therapy/Procedure

8Therapeutics
01/2021 - 03/2008
2Oral Administration
10/2022 - 01/2022
1Drug Tapering
10/2021
1Drug Therapy (Chemotherapy)
03/2016
1Transplantation
12/2015
1Heart Transplantation (Grafting, Heart)
10/2014
1Microbubbles
12/2011